College football betting lines: Indiana-Oregon, Alabama-Missouri highlight Week 7

Written by: ESPN on Monday 10, 2025

There are three ranked matchups this weekend, starting with No. 1 Ohio State on the road against No. 17 Illinois and No. 8 Alabama also on the road against No. 14 Missouri, both at noon ET.

At 3:30 p.m. ET, No. 7 Indiana and No. 3 Oregon clash in their first head-to-head matchup as Big Ten rivals. Both teams have at least a 60% chance to reach the College Football Playoff, even with a loss, according to ESPN Analytics.

Texas Tech entered the top 10 for the first time since 2013, and No. 9 is their highest ranking since 2008, when they rose as high as No. 2. No. 16 Notre Dame and No. 25 Florida State are the only two-loss teams ranked this week.

Elsewhere, Florida is playing an AP top-10 opponent (No. 5 Texas A&M) for a fourth straight game, making them the first team to do so in the same regular season since 1968, according to ESPN Research.

All times Eastern. For latest lines, go to ESPN BET 

No. 24 South Florida at North Texas -1.5
Friday, 7:30 p.m., ESPN2

Records: South Florida 4-1, 2-1 vs. AP teams; North Texas 5-0, 0-0 vs. AP teams
Opening line: North Texas -1.5, O/U 66.5
Money line: South Florida (-110); North Texas (-110)
Over/under: 67.5 (O -105, U -115)


FPI Projection North Texas by 0.8 points with a 53% probability to win game outright

No. 1 Ohio State -14.5 at No. 17 Illinois
Saturday, Noon, Fox

Records: Ohio State 5-0, 1-0 vs. AP teams; Illinois 5-1, 1-1 vs. AP teams
Opening line: Ohio State -16.5, O/U 48.5
Money line: Ohio State (-700); Illinois (+450)
Over/under: 50.5 (O -115, U -105)


FPI Projection Ohio State by 10.7 points with a 82% probability to win game outright

No. 8 Alabama -2.5 at No. 14 Missouri
Saturday, Noon, ABC

Records: Alabama 4-1, 2-0 vs. AP teams; Missouri 5-0, 0-0 vs. AP teams
Line Movement Alert: Opened Alabama -5.5, O/U 54.5
Money line: Alabama (-150); Missouri (+130)
Over/under: 52.5 (O -120, U EVEN)


FPI Projection Alabama by 3.4 points with a 63% probability to win game outright

Pittsburgh at No. 25 Florida State -10.5
Saturday, Noon, ESPN

Records: Pittsburgh 3-2, 0-0 vs. AP teams; Florida State 3-2, 1-1 vs. AP teams
Opening line: Florida State -9.5, O/U 58.5
Money line: Pittsburgh (+300); Florida State (-400)
Over/under: 58.5 (O -105, U -115)


FPI Projection Florida State by 8.1 points with a 77% probability to win game outright

Washington State at No. 4 Ole Miss -32.5
Saturday, 12:45 p.m., SEC Network

Records: Washington State 3-2, 0-0 vs. AP teams; Ole Miss 5-0, 1-0 vs. AP teams
Opening line: Ole Miss -32.5, O/U 59.5
Money line: Off
Over/under: 59.5 (O -105, U -115)


FPI Projection Ole Miss by 34.7 points with a 98% probability to win game outright

No. 7 Indiana at No. 3 Oregon -7.5
Saturday, 3:30 p.m., CBS

Records: Indiana 5-0, 1-0 vs. AP teams; Oregon 5-0, 1-0 vs. AP teams
Opening line: Oregon -7.5, O/U 54.5
Money line: Indiana (+250); Oregon (-300)
Over/under: 55.5 (O -105, U -115)


FPI Projection Oregon by 5.2 points with a 69% probability to win game outright

No. 6 Oklahoma at Texas -2.5
Saturday, 3:30 p.m., ABC

Records: Oklahoma 5-0, 2-0 vs. AP teams; Texas 3-2, 0-1 vs. AP teams
Opening line: Texas -2.5, O/U 42.5
Money line: Oklahoma (+120); Texas (-140)
Over/under: 42.5 (O -115, U -105)


FPI Projection Texas by 2.8 points with a 61% probability to win game outright

Virginia Tech at No. 13 Georgia Tech -14.5
Saturday, 3:30 p.m., ACC Network

Records: Virginia Tech 2-4, 0-1 vs. AP teams; Georgia Tech 5-0, 1-0 vs. AP teams
Opening line: Georgia Tech -14.5, O/U 55.5
Money line: Virginia Tech (+475); Georgia Tech (-750)
Over/under: 55.5 (O -115, U -105)


FPI Projection Georgia Tech by 9.4 points with a 80% probability to win game outright

NC State at No. 16 Notre Dame -21.5
Saturday, 3:30 p.m., Peacock

Records: NC State 4-2, 0-0 vs. AP teams; Notre Dame 3-2, 0-2 vs. AP teams
Opening line: Notre Dame -22.5, O/U 62.5
Money line: NC State (+1000); Notre Dame (-2000)
Over/under: 61.5 (O -105, U -115)


FPI Projection Notre Dame by 19.5 points with a 92% probability to win game outright

No. 22 Iowa State -3.5 at Colorado
Saturday, 3:30 p.m., ESPN

Records: Iowa State 5-1, 1-0 vs. AP teams; Colorado 2-4, 0-1 vs. AP teams
Opening line: Iowa State -4.5, O/U 53.5
Money line: Iowa State (-175); Colorado (+150)
Over/under: 53.5 (O -105, U -115)


FPI Projection Iowa State by 3.3 points with a 63% probability to win game outright

Arkansas at No. 12 Tennessee -12.5
Saturday, 4:15 p.m., SEC Network

Records: Arkansas 2-3, 0-2 vs. AP teams; Tennessee 4-1, 0-1 vs. AP teams
Opening line: Tennessee -12.5, O/U 69.5
Money line: Arkansas (+380); Tennessee (-550)
Over/under: 69.5 (O -105, U -115)


FPI Projection Tennessee by 10.7 points with a 83% probability to win game outright

Florida at No. 5 Texas A&M -7.5
Saturday, 7 p.m., ESPN

Records: Florida 2-3, 1-2 vs. AP teams; Texas A&M 5-0, 1-0 vs. AP teams
Opening line: Texas A&M -8.5, O/U 47.5
Money line: Florida (+230); Texas A&M (-280)
Over/under: 46.5 (O -115, U -105)


FPI Projection Texas A&M by 6.7 points with a 74% probability to win game outright

Kansas at No. 9 Texas Tech -13.5
Saturday, 7:30 p.m., Fox

Records: Kansas 4-2, 0-0 vs. AP teams; Texas Tech 5-0, 1-0 vs. AP teams
Opening line: Texas Tech -14.5, O/U 60.5
Money line: Kansas (+450); Texas Tech (-700)
Over/under: 60.5 (O -110, U -110)


FPI Projection Texas Tech by 7 points with a 74% probability to win game outright

No. 10 Georgia -3.5 at Auburn
Saturday, 7:30 p.m., ABC

Records: Georgia 4-1, 1-1 vs. AP teams; Auburn 3-2, 0-2 vs. AP teams
Opening line: Georgia -3.5, O/U 46.5
Money line: Georgia (-175); Auburn (+150)
Over/under: 46.5 (O -115, U -105)


FPI Projection Georgia by 3.5 points with a 64% probability to win game outright

No. 15 Michigan at USC -2.5
Saturday, 7:30 p.m., NBC

Records: Michigan 4-1, 0-1 vs. AP teams; USC 4-1, 0-1 vs. AP teams
Opening line: USC -1.5, O/U 57.5
Money line: Michigan (+110); USC (-130)
Over/under: 57.5 (O -115, U -105)


FPI Projection USC by 4.8 points with a 69% probability to win game outright

South Carolina at No. 11 LSU -8.5
Saturday, 7:45 p.m., SEC Network

Records: South Carolina 3-2, 0-1 vs. AP teams; LSU 4-1, 1-1 vs. AP teams
Opening line: LSU -9.5, O/U 44.5
Money line: South Carolina (+270); LSU (-340)
Over/under: 44.5 (O -105, U -115)


FPI Projection LSU by 6.3 points with a 73% probability to win game outright

No. 18 BYU -1.5 at Arizona
Saturday, 8 p.m., ESPN2

Records: BYU 5-0, 0-0 vs. AP teams; Arizona 4-1, 0-1 vs. AP teams
Opening line: BYU -2.5, O/U 47.5
Money line: BYU (-125); Arizona (+105)
Over/under: 47.5 (O -110, U -110)


FPI Projection BYU by 5.1 points with a 70% probability to win game outright

No. 21 Arizona State at Utah -5.5
Saturday, 10:15 p.m., ESPN

Records: Arizona State 4-1, 1-0 vs. AP teams; Utah 4-1, 0-1 vs. AP teams
Opening line: Utah -4.5, O/U 48.5
Money line: Arizona State (+170); Utah (-200)
Over/under: 48.5 (O -110, U -110)


FPI Projection Utah by 5.3 points with a 70% probability to win game outright